The CISD2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CISD2. This antibody recognizes Human, Mouse, and Rat antigen. The CISD2 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Function: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Subunit Structure: Homodimer. Interacts with BCL2; the interaction is direct and disrupted by BIK interaction with BCL2. Interacts with BCL2L1. Interacts with ITPR1.
Similarity: Belongs to the CISD protein family. CISD2 subfamily